Tuesday, May 17, 2022
| Away | Home | Score | Date | Time | |
|---|---|---|---|---|---|
| Southern Maryland Blue Crabs | Gastonia Honey Hunters | - | May 17, 2022 | 06:15 pm EDT | Scheduled |
| Lancaster Barnstormers | York Revolution | - | May 17, 2022 | 06:30 pm EDT | Scheduled |
| Staten Island Ferry Hawks | Long Island Ducks | - | May 17, 2022 | 06:35 pm EDT | Scheduled |
| Lexington Legends | High Point Rockers | - | May 17, 2022 | 06:35 pm EDT | Scheduled |
| Charleston Dirty Birds | Kentucky Wild Health Genomes | - | May 17, 2022 | 06:35 pm EDT | Scheduled |